GLP-1 Agonist
TB-500
TB-500 is a synthetic peptide fragment studied in laboratory research for its role in actin regulation, cell migration, and tissue remodeling investigations. Supplied at 10mg with ≥99% purity and verified by LC-MS and HPLC analysis. This product is intended strictly for laboratory research use only and is not for human or animal consumption.
Mechanism of Action
The primary biochemical activity of thymosin beta-4 involves 1:1 binding of monomeric G-actin through the LKKTETQ sequence motif, which sequesters actin monomers and prevents spontaneous polymerization into F-actin filaments. This mechanism modulates cytoskeletal dynamics and is associated with enhanced cellular motility.
Research has demonstrated that thymosin beta-4 activates integrin-linked kinase (ILK), a serine-threonine kinase involved in cell survival signaling through the Akt/protein kinase B pathway. In endothelial cell models, this activation has been associated with enhanced tube formation and capillary outgrowth, suggesting involvement in angiogenic processes. Additional studies indicate that thymosin beta-4 may modulate inflammatory responses through regulation of NF-kB signaling and promotion of anti-inflammatory mediators in tissue microenvironments.
Research Applications
- → Research demonstrates 1:1 G-actin sequestration through the LKKTETQ binding domain, modulating cytoskeletal reorganization and cell migration
- → Studies indicate activation of integrin-linked kinase (ILK) and downstream Akt survival signaling in cardiac cell models
- → Preclinical corneal wound healing studies show accelerated re-epithelialization and reduced inflammatory markers
- → Endothelial cell assays demonstrate enhanced tube formation, migration, and capillary outgrowth in angiogenesis models
Analytical Validation
TB-500 is verified via LC-MS and HPLC analysis. Each lot is tested for identity, purity (≥99% target), and endotoxin levels. Full certificate of analysis is available upon request.
