Mecanismo de acción

TIRZ simultaneously engages two incretin receptors that play complementary roles in metabolic regulation. GIP receptor activation on pancreatic beta cells potentiates glucose-dependent insulin secretion, while GLP-1 receptor agonism reduces glucagon secretion and slows gastric emptying. The dual-receptor approach produces synergistic effects on glycemic control and energy balance that exceed what has been observed with single-receptor agonists in comparative studies.

The GIP receptor component also acts on adipose tissue, where it influences lipid metabolism and may contribute to preferential fat mass reduction. In clinical trials, the molecule has demonstrated effects on hepatic lipid content, with studies showing substantial reductions in liver fat. The C20 fatty diacid modification enables non-covalent albumin binding, resulting in a half-life of approximately 5 days that supports once-weekly administration.

Aplicaciones de investigación

• → SURPASS clinical trial program demonstrated superior glycemic control compared to insulin and single-receptor GLP-1 agonists across multiple phase 3 studies
• → SURMOUNT-1 trial reported that 85-91% of participants in the treatment groups achieved 5% or greater weight reduction
• → SURPASS-3 MRI sub-study showed liver fat reductions of 29.8% to 47.1% compared to 11.2% with insulin degludec at 52 weeks
• → Post-hoc analyses demonstrated improvements in systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, and triglyceride levels
• → Research indicates preferential reduction in fat mass with relative preservation of lean mass in body composition studies

Validación analítica

TIRZ is verified via LC-MS and HPLC analysis. Each lot is tested for identity, purity (≥99% target), and endotoxin levels. Full certificate of analysis is available upon request.